Nikkei ends at 16-month low on yen, U.S. economy

(Updates to close)

TOKYO, Nov 21 (Reuters) - Japan's Nikkei average ended at a 16-month closing low on Wednesday, as a stronger yen and a weaker outlook for the U.S. economy depressed exporters such as Honda Motor Co Ltd .

The Nikkei ended down 2.5 percent or 373.86 points at 14,837.66, its lowest close since July 24, 2006.

The broader TOPIX fell to a more than two-year low, down 2.1 ...